#5393 INFLUENCE OF CELLULAR INFLAMMATION ON THE OUTCOME OF KIDNEY TRANSPLANTATION AFTER RECURRENCE OF IGA NEPHROPATHY

Abstract Background and Aims The recurrence of IgA nephropathy (rIgAN) worsens the prognosis renal transplantation, representing third cause loss in these recipients. Several variables at time recurrence, such as worse function, greater proteinuria, previous steroid withdrawal, MEST-C histological findings have been associated with a higher risk graft after recurrence. presence clinical or subclinical inflammation has kidney loss, but it is not precisely known how influences outcome patients rIgAN. Method A multicenter retrospective study was carried out including transplant recipients biopsy-proven underlying disease which primary had verified by means biopsy Banff criteria were available could be reviewed. Cellular defined according to scores “t” “i” ≥2. main endpoint progression CKD stage 5 death censored-graft (DCGL). Results 118 included an age 47 ± 14 years 80% male, mean 65 69 months post-transplant follow-up 70 months. After 34 (28.8%) transplants lost 35 28 months, excluding death. Using univariate Cox regression, factors related systolic blood pressure (HR 1.039, 95%CI 1.016-1.064, p = 0.001), glomerular filtration rate 0.948, 0.922-0.974, <0.001), logarithm proteinuria 15.836, 95% CI 5.504-45.565, < Oxford-C score 3.490, 2.137-5.699, interstitial fibrosis 2.173, 1.362-3.468, 0.001) cellular 2.458, 1.237-4.884, 0.010). multivariate analysis, remained significantly DCGL 2.338, 1.077-5.075, 0.032). independently pressure, rate, score. Conclusion In addition previously described usually evolution native we observed that We suggest considering for acute better understand subsequent